Preliminary reports indicate conolidine may well inhibit unique ion channels, minimizing neuronal excitability and restricting ache indicators. This mechanism is especially applicable in neuropathic suffering, where by irregular signaling leads to persistent irritation. On top of that, conolidine seems to influence G protein-coupled receptor (GPCR)

This compound was also examined for mu-opioid receptor action, and like conolidine, was uncovered to possess no action at the website. Employing a similar paw injection check, several choices with greater efficacy had been located that inhibited the Original pain response, indicating opiate-like exercise. Offered different mechanisms of such conoli